London:: Printed for J. Buckland, W. Strahan . 1782. hardcover. 8vo. , xv, , 560,  pp. Engraved frontispiece [bottom corner. torn with some loss]; some leaves dog-eared, evidence of mold, water-. stains. Original calf binding a remnant; considerable wear, spine. disintegrated, toned paper mounted on both covers, also the endleaves. are patched. All said, this volume preserves a remarkable association. copy. Preserved in a modern decorative illustrated drop-back box.. INSCRIBED BY EDWARD JENNER, THE DISCOVERER OF THE FIRST MEDICAL VACCINE, TO HIS WIFE CATHERINE JENNER. Furthermore the provenance of this book shows that its ownership passed to the family line of Sarah Nelmes, the original milkmaid [according to Paul Saunders she was from a prosperous family] who was infected with cowpox and was the source of Jenners inspiration to use a form of the virus to inoculate James Phipps against the more virulent smallpox. AN EXTRAORDINARY ASSOCIATION COPY INSCRIBED BY EDWARD JENNER TO HIS BELOVED WIFE CATHARINE AND KEPT IN THE FAMILY LINE OF SARAH NELMES THE ORIGINAL COWPOX DONOR. Edward Jenner, born in mid- 18th century England, would eventually become one of the most famous scientists in medical history and the so-named Father of Immunology. After observing that cowpox infection seemed to protect humans against smallpox, Jenner inoculated an eight-year-old boy with cowpox matter from a blister on the hand of an English milkmaid. He then repeatedly attempted to challenge the cowpox inoculation by exposing the boy [James Phipps] to smallpox materialbut the boy never fell ill. Jenner had demonstrated smallpox immunization. SARAH NELMES, case XVI in Jenners famous account, is the subject also of the famous plates showing the pustule on her hand, shown in color of Jenners book [please ask to request more information]. REFERENCES: See: Hervé Bazin, Vaccinations: a History: From Lady Montagu to Jenner, Pasteur and Genetic Engineering, John Libbey Eurotext Ltd., 2011, page 65; Ann Jannetta, The Vaccinators: Smallpox, Medical Knowledge, and the Opening of Japan, Stanford University Press, (2007), page 29. Meyer Friedman; Gerald W. Friedland, Medicines 10 Greatest Discoveries, Yale University Press, 1998. [Chapter 4 is devoted to Jenners discovery]. . . (Inventory #: M13062)
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