Two wood-engraved text illustrations. 16 pp. 8vo, modern green half-calf & marbled boards, spine lettered in gilt. London: T. Savill, 1848. First book edition, inscribed by the author on the title-page, "With the Author's Comps." Snow (1813-58), was the first physician to fully devote himself to anesthesia. A trusted expert in the fledgling field of anesthesiology, he was chosen to administer chloroform on Queen Victoria for the birth of her eighth child, Prince Leopold. Snow was also the first practitioner of anesthetics to undertake systematic pharmacological studies on anesthetic agents. "John Snow, a British surgeon and physician, was a pioneer in clinical anesthesia and medical hygiene. In this paper he compared the safety of ether and chloroform anesthetics... Snow then compared ether and chloroform, attributing the anesthetic properties to differences in their solubility in blood. He believed the brain to be the major site of action for both agents. When comparing the effectiveness, desirability and safety of the two drugs, he found chloroform less pungent, taking less space and therefore allowing more air for the patient, and exciting less saliva production. On the other hand, he observed that chloroform was potentially more dangerous than ether, especially in unskilled hands."-Sim, The Heritage of Anesthesia, p. 133. A nice copy and very rare. . (Inventory #: HillBibl-5354)
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