One woodcut illus. in the text. xliv, 443 pp., 28 pp. of Churchill's ads dated September, 1858 bound in at end. 8vo, modern red half-morocco and cloth, t.e.g. London: J. Churchill, 1858. First edition. Snow, the first specialist in clinical anesthesiology, placed the administration of ether and chloroform on a scientific basis with the publication of the present treatise. Snow was the first to perform experimental research on the physiology of the anesthetized state, and the information obtained during the course of his investigations influenced the construction of the first regulating inhaler for clinical use. He experimented on animals to practice endotracheal anesthesia and the technique of carbon dioxide rebreathing, described intercostal paralysis, determined anesthetic concentrations in air and blood, experimented with dozens of anesthetic agents (including amylene, which he was the first to administer), and defined the five stages of anesthesia. Snow's On Chloroform appeared shortly after his untimely death from cerebral hemorrhage; it includes a definitive biography of Snow by his friend Benjamin Ward Richardson, and a large index. Deeply concerned by the frequent misapplication of chloroform that resulted in numerous deaths, Snow set out to provide extensive information on proper use of the drug, which was much more fast-acting than ether. He devotes an entire section to cases, some in the United States, which resulted in the death of the patient. A nice copy, preserved in a slipcase, with the ownership inscription: "E. Blackwell 355 Lexington Ave. N.Y. City Oct. 18 1883" on the free front endleaf. ❧ Duncum, Development of Inhalation Anaesthesia, pp. 17-22. Garrison-Morton 5666. . (Inventory #: HillBibl-5355)
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