An Acute Myxedematous Condition, with Tachycardia, Glycosuria, Melana, Mania and Death. [Offprint].
by OSLER, Sir William (1849-1919).
[New York]:: American Neurological Association, 1898., 1898. Offprint. 25.5 cm. 7,  pp. Self-printed wrappers. Near fine. First issue. "In 1989 Sir William Osler detailed the case of a 31-year old man suffering from 'an acute myxedematous condition, with tachycardia, glycosuria, melena, mania and death." In particular, Osler was impressed by the rapid weight gain and the 'bloated' appearance of his patient's face. Unfortunately, however, the constellation of symptoms and signs that we now attribute to glucocorticoid excess had not been described and the patient succumbed while being treated for hypothyroidism." – Michael Fowler & Lewis S. Blevins, "A Rational Approach of the Patient suspected of having Cushing's Syndrome," Cushing's Syndrome, 2002. "It has been suggested (Altschule, M.D., New England J. of Med., 1980, cccii, 1153-1155) that this case is an early description of Cushing's syndrome, in which, regrettably, no post-mortem examination was performed." – Golden & Roland. Golden & Roland 714. [HM] (Inventory #: M13509)
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