Recherches Anatomico-Pathologiques sur la Phthisie; Precedees du rapport fait a l'Academie Royale de medecine par MM. Bourdois, Royer-Collard et Chomel.
by LOUIS, Pierre-Charles-Alexandre (1787-1872).
Paris:: Gabon, 1825., 1825. Thick 8vo. xxiv, 16, 560 pp. Half title (as a fragment); foxed and/or browned, cellophane tape applied to gutter pp. 544-545 (index section). Modern maroon half-cloth with marbled boards, paper spine label. Untrimmed, as issued. Very good. First edition. "Louis' researches were based on 358 dissections and 1,960 clinical cases, and included a numerical study of extra-pulmonary lesions. First edition in English, London, 1835. English translation, Boston, 1836. A translation of the 2nd edition was published by the Sydenham Society in 1844." - Garrison and Morton 3221. "One of the most influential figures in French medicine, Louis received his medical degree from the University of Paris in 1813. He practiced medicine for seventeen years in Russia but left to undertake further study after becoming distressed over the ineffectiveness of local measures taken to deal with a diphtheria epidemic. Returning to Paris, he embarked on the life-long study of the fatal diseases with particular emphasis on tuberculosis and typhoid fever. Working with a large number of patients, Louis collected detailed statistics on every case using the results as instruments of diagnosis and therapy. His reliance on the statistical analysis of disease, though sometimes faulty, helped put to rest the concept of a priori theories of medicine so pervasive at the time. This work on tuberculosis, which established Louis' reputation as a clinician, gives a numerical study of extrapulmonary lesions based on 358 dissections and 1,960 clinical cases." – Heirs. "Louis was one of the greatest of the French clinician-pathologists of the early nineteenth century. He had a remarkable capacity for precise unbiased observations and for clear and beautifully written descriptions. Louis confined his observations to tuberculosis, and it seems to us that he gave a clear over-all picture of the disease hardly surpassed by Laennec. The book is in two parts. The first part deals systematically with the lesions, illustrated by careful autopsy reports, many of which might well have come from a modern department of pathology. In the second part the clinical features are admirably detailed. The various stages of the disease - early, late, etc. - are discussed, as well as the symptoms of involvement of organs other than the lung . As with Laennec, any serious student of tuberculosis must carefully study Louis's book; one cannot do justice to it in a few words." - Bloomfield, Communicable Diseases, p. 201. "The arbitrary doctrines of Broussais were overthrown by P.C.A. Louis, the founder of medical statistics. Louis thought that the fallacies of an a priori theory, like that of Broussais, can easily be brought out and thrown into relief by good statistics and that statistics can sometimes be used as an instrument of precision in cases where proper experimental methods are wanting. To establish his own results, Louis made over 5000 postmortems investigations. He was the first, after Floyer, to use the watch in timing the pulse. Through his American pupils, Holmes, Gerhard, the Jacksons, the Shattucks and others, he exerted a powerful influence upon the advancement of medical science in the Eastern United States. The strong stand which Louis took in favor of facts and figures, as against the sterile theorizing of the past, appealed especially to the keen, practical common sense of these northern physicians". – Garrison, History of Medicine, pp. 410-411. Garrison and Morton 3221; Heirs of Hippocrates 1438; Osler, Alabama Student, p. 194; Waller 6034 (2nd ed., 1843); Wellcome III, p. 551.
(Inventory #: MMRM1245)
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