The physiology of the immediate reaction of anaphylaxis in the guinea-pig. Offprint. Pres. copy

Auer, John (1875-1948) and Paul. A. Lewis (1879-1929). The physiology of the immediate reaction of anaphylaxis in the guinea-pig. Offprint from Journal of Experimental Medicine 12 (1910). 151-175pp. 4 folding plates numbered VI - IX. 265 x 183 mm. (uncut). Original printed wrappers, one or two tiny chips. Very good. Presentation Copy, inscribed by Auer on the front wrapper: "With best regards John J. Auer." From the library of Lafayette B. Mendel (1872-1935), with his stamp on the front wrapper; Yale University School of Medicine library stamp also on front wrapper.

First Edition, Offprint Issue. Garrison-Morton.com 2600. "John Auer and Paul Lewis were the first to recognize asphyxiation as the cause of death in anaphylaxis. Before Auer and Lewis's studies, it was believed that anaphylaxis was a reaction of the central nervous system. In pithing the guinea pigs used in their study, Auer and Lewis were able to show that the peripheral nervous system was responsible for the onset of anaphylaxis. They hypothesized that the asphyxiation observed was the result of bronchial spasms. Operating on this idea, they administered atropine to suppress such spasms, and found this treatment to be effective" (Wikipedia article on Auer). Auer received his medical degree from Johns Hopkins in 1902 and served as House Officer at Johns Hopkins Hospital in 1902-3, where he spent time in Osler's ward.

This inscribed copy is from the library of American biochemist Lafayette B. Mendel, discoverer of vitamin A.